psychosis after covid vaccine


They include codes for COVID-19 screening; suspected exposure to COVID-19; personal history of COVID-19; multisystem . Unable to load your collection due to an error, Unable to load your delegates due to an error. The Conversation. In this case, treatment with oral risperidone 3 mg daily and oral sertraline 100 mg daily alleviated some of our patients overt persecutory and referential delusions. For instance, a 2021 study concluded that pediatric patients with COVID-19 and neuropsychiatric symptoms, such as severe anxiety and delusional psychosis, may have antiSARS-CoV-2 and antineuronal antibodies in their CSF [cerebral spinal fluid] and may respond to immunotherapy.. HHS Vulnerability Disclosure, Help Far-right U.S. news outlet The Epoch Times reported on March 6 that 966 people had died after having the Pfizer or Moderna COVID vaccines. A female in her 20's presented to the Emergency Department (ED) with a chief complaint of urinary frequency 1 week after receiving her first dose of the Pfizer-BioNTech COVID-19 vaccine ().The patient's family stated she had increasingly frequent bouts of anxiety, decreased mentally acuity, insomnia, and a fixation that she suffered from irritable bowels and kidney disease. "There was nothing we could do to get him to relax and calm down," Jennifer Price said. -, Goldsmith D.R., Rapaport M.H., Miller B.J. Chills and swollen lymph nodes can also occur. Schizophr Bull. Psychiatry. You might run a fever and experience body aches, headaches and tiredness for a day or two. and transmitted securely. Even one night of sleep deprivation causes a drastic decline in killer T-cells, Marcum says. But there's more to it. (2020). It can be associated with: A recent New York Times article on this condition detailed the accounts of several anonymous cases, but empirical evidence in broader populations is still lacking. Provided by (2020). However, enough cases have shown up where I think while some of us, such as myself, might have been somewhat skeptical at the first reports, I think most of us are growing less skeptical as we see more and more cases where we're having to ask ourselves if COVID plays a causal role in either the seriousness of the problem or just the entire problem.". Would you like email updates of new search results? Another important aspect of this case was the lack of evidence of severe systemic illness or respiratory illness and no reported use of steroids or other medications, which could have been confounding factors regarding Mr Morenos ability to precipitate psychotic symptoms. Polsek D. Huremovi D, ed. (2020) More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Cases of post-infectious psychosis have occurred with other viruses, including the 1918 Spanish flu and coronaviruses SARS and MERS. 2018;69:540547. Before Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms. Starting from the second week, the patient manifested delusions of persecution, delusions of influence, thoughts insertion, and delusional behaviour, culminating in the suicide attempt. Many of the patients had mild symptoms of COVID-19. When he returned home, she said he was a different man and that he worried about things that were not happening. Acute psychosis induced by mRNA-based COVID-19 vaccine in adolescents: A pediatric case report. August 18, 2020. Despite being medically stable, Mr Moreno exhibited gross symptoms of psychosis that could not be managed in the community and led to another hospitalization at our medical center. People with post-COVID psychosis also frequently have insight into the way they are feeling. Fever. There is new evidence that brain areas undergoing change in mild COVID infection may also be areas that change in people who are at risk of, or who are experiencing, first-episode psychosis (that is, not after COVID infection). 1-3 Recently published studies have shown that COVID-19 can cause severe neuropsychological stress-inducing psychosis in affected patients. Federal government websites often end in .gov or .mil. Ana Florence, PhD. Bartley CM, et al. Rosman Y, Lavi N, Meir-Shafrir K, Lachover-Roth I, Cohen-Engler A, Mekori YA, Confino-Cohen R. J Allergy Clin Immunol Pract. COVID Can Cause Forgetfulness, Psychosis, Mania or a Stutter The virus induces neurological symptoms that persist long after the pandemic ends By Stephani Sutherland on January 21, 2021 Credit:. 5. The studys authors recommended clinicians be on the lookout for new onset of psychiatric disorders, even in patients with no history of mental illness. Boldrini M, Canoll PD, Klein RS. 2020;87:34-39. A 2020 study in Britain found that 10 out of 153 participants with neurological or psychiatric symptoms hospitalized with COVID-19 had new-onset psychosis.. All rights reserved. Just how common is post-COVID psychosis? Xiong J, et al. government site. As one 2020 study notes, there have been no detailed reports of patients developing persistent psychotic symptoms following COVID-19.. Vaccines are crucial to ending the COVID-19 pandemic. COVID is not the first virus to be linked to psychosis. The investigations of the patient did not support any structural changes of the brain, any severe medical conditions, a neurological abnormality, a confusion or a state of unconsciousness or alterations in laboratory tests. 8600 Rockville Pike Use this form if you have come across a typo, inaccuracy or would like to send an edit request for the content on this page. According to the report on 12-15-22, she received a COVID-19 (Moderna) mRNA infection with a regular flu shot. Prior to COVID-19 infection, the patient was cognitively intact at baseline but preoccupied with visiting his deceased wifes grave in Peru. A yearly screening can help, KidsMatter: Helping youth say yes to endless possibilities, Healthy Driven Stories with Mary Lou Mastro. Experts recommend all youth ages 12 and up be screened for depression at least once a year. Bhojani S., Aldana-Bernier L., Sikder M., Pawelzik T. Psychotic disorder after contact with a potentially rabid animal and post-exposure prophylactic anti-rabies treatment. Among the various adverse events which might observed after COVID-19 vaccination, the occurrence of functionalonce called psychogenicneurological disorders (FNDs) might be a challenging issue for healthcare providers, media and public opinion with a negative impact on vaccination campaigns. shortness of breath, chest pain, leg swelling or persistent abdominal pain. Online ahead of print. "That was heartbreaking.". The CDC . Muscle soreness at the injection site is an especially common vaccine side effect, and your instinct might be to let your arm hang limp as often as possible. Some of the effects of COVID-19 could linger for years to come. Depression during COVID-19 pandemic? COVID-19 Information Center: get the latest on vaccines, testing, screening, visitor policy and post-COVID support >>. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. A number of cases of cardiac, gastrointestinal, and psychiatric side effects have been reported as rare side effects associated with the COVID-19 vaccine. He died by suicide 16 days after his COVID-19 diagnosis. Psychiatry Res. Neither your address nor the recipient's address will be used for any other purpose. It's been over a year since COVID-19 lockdowns were put in place. If you cannot upgrade your browser, you can remain on this site. 18. Though much remains to be learned about COVID-19 and its longtime impact, Dr. Wayne Nguyen, pediatric psychiatrist and medical director of the Cherese Mari Laulhere Mental Health Inpatient Center at CHOC, reassures parents that psychosis is likely not a byproduct of COVID-19 in children. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Psychosis is a condition characterised by confused thoughts, delusions and hallucinations. 2022 May;52(3):511-525. Is COVID-19 the cause of psychosis or just a coincidence? Pillay J, Gaudet L, Wingert A, Bialy L, Mackie AS, Paterson DI, Hartling L. BMJ. The mans widow told WGN News that her husband had been hospitalized for COVID-19 and put on oxygen. 2020;291:113254. [.] It has been documented that like COVID-19, these viruses have been able to produce symptoms of psychosis in patients with no prior psychiatric conditions. In another case, a 43-year-old Bulgarian man began experiencing psychois two days after he was discharged from hospital for severe COVID. There are possibilities that some of the neurotoxins resulting from the immune reactions may pass the blood-brain barrier into the brain, which may cause this severe mental disorder, says Daniel Boyer, MD, a researcher specializing in molecular biology, pharmacology, and pathology at the Farr Institute. Panariello A, Bassetti R, Radice A, et al. -. 1. People who've recovered from COVID-19 also should definitely get . Animal coronaviruses can infect people and spread, as we have seen with MERS-CoV, SARS-CoV, and most recently with SARS-CoV-2, which originated from bats. Safety of BNT162b2 mRNA COVID-19 vaccine in patients with mast cell disorders. Good mental health isn't defined by whether you live with a mental health condition or not. Covid-related psychiatric issues At least since the 1918 influenza epidemic doctors have been aware of neurological and psychiatric consequences from systemic viral infections. "People who already have a preexisting or previously declared mental illness are at greater risk of decompensation[or the failure to generate effective psychological coping mechanisms]during this time," McIntyre says. Mr Morenos condition deteriorated, which led to a brief psychiatric hospitalization. Majeed A, Papaluca M, Molokhia M. Assessing the long-term safety and efficacy of COVID-19 vaccines. They can recognise this is not normal for them, and something has changed in the way they are thinking. Our physicians and other experts will post about the steps you can take today to stay healthy and fit for years to come. A few of these videos have been viewed millions of times by the public. Authors Samuel Reinfeld 1 , Ricardo Cceda 2 , Roberto Gil 1 , Harrison Strom 1 , Mason Chacko 3 Affiliations "Labs suggest that the virus may actually be crossing the blood brain barrier, and some of the changes that we see in [the] brain related to major psychotic disorders are being observed," the doctor explained. Accessibility Kevin Wang 1:18 am, Feb 21, 2017. Based on the years of experience as a Phys.org medical research channel, started in April 2011, Medical Xpress became a separate website. 2016;21(12):16961709. If the current surge in Covid-19 cases has coincided with the decline of your own mental well-being, you're not alone. We don't yet know what exactly about the viral illness can cause the psychotic disorder.". Case Narrative. The potential impact of COVID-19 on psychosis: a rapid review of contemporary epidemic and pandemic research. Burr T, Barton C, Doll E, Lakhotia A, Sweeney M. N-methyl-d-aspartate receptor encephalitis associated with COVID-19 infection in a toddler. . Can new onset psychosis occur after mRNA based COVID-19 vaccine administration? All rights reserved, With Tax Season Starting Soon, Here's What To Know Before You File, Thousands of Cook County Homeowners Could Be Getting a Refund. DAVOS, Switzerland, Jan 18 (Reuters) - Moderna chief executive Stephane Bancel said on Wednesday the U.S. company was in active discussions to supply COVID-19 vaccines to China. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Here's what psychosis may feel and look like. None of the individuals had a previous history of psychosis. MeSH Psychotic symptoms in COVID-19 patients. Accessibility Epub 2022 Jan 24. Some research has indicated that the bodys reaction to COVID-19 could lead to inflammation around the brain which in turn can affect a persons mental health. Schizophr. 7. However, we do not guarantee individual replies due to the high volume of messages. "He just kept saying I'm just so scared, I'm just so scared, and he couldn't even tell you what he was scared about.". PMC 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: A retrospective cohort study using electronic health records. While COVID psychosis can affect people without any history of mental illness, those with mental health conditions may be at a higher risk of COVID-19, according to the CDC. (2021). Lopez-Leon S, et al. Vaccines are crucial to ending the COVID-19 pandemic. The research published today in the journal Brain . From what is being observed, those suffering from severe depression may display a slow response post-inoculation. Psychiatry of Pandemics: A Mental Health Response to Infection Outbreak. Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns. Psych Central does not provide medical advice, diagnosis, or treatment. Doctors prescribed Ben Price anxiety medication, but his condition only got worse. COVID psychosis is a mental health condition experienced in connection with COVID-19 that may cause symptoms and episodes of psychosis. Long COVID: An overview. Your feedback is important to us. Disclaimer, National Library of Medicine Yi Y, Lagniton PNP, Ye S, et al. Psychosis is a symptom of many health conditions, including schizophrenia. (Evan Mitsui/CBC) A little over 23 per cent . Trials. To see the full site, please upgrade your browser to the most recent version of Safari, Chrome, Firefox or Internet Explorer. This collaborative awareness of a new entity of neuropsychiatric illness resulting from COVID-19 could ideally lead to better diagnostic modalities such as advanced brain imaging techniques, SARS-CoV2 CSF PCR tests, and potential future peer-reviewed, evidence-based treatment recommendations for this emerging psychopathology. Dr Azubuogu is affiliated with Nassau University Medical Center. outlines a handful of cases involving people in their 30s, 40s and 50s who had never been diagnosed with a mental health illness but developed psychosis within weeks after testing positive for COVID-19. Mol. Some experts suggest that brain-related effects from COVID-19 may be linked to the bodys immune system response or vascular problems and inflammation caused by the disease process. The risk is low but episodes are frightening. The link between mental health and ADHD is strongso why aren't we paying attention? Read the original article. Mental Health Added to COVID-19 Risk List: What Does It Mean for You? One U.K. study published in the Lancet in October 2020 found that of 153 people who were diagnosed with COVID-19 early in the pandemic, 10 suffered new-onset psychotic episodes following their. difficulty with your speech, weakness, drowsiness or seizures. Marcum explains that when depression is severe, it can sometimes be difficult to get out of bed and engage in simple tasks like showering, proper hand-washing, and eating healthily. Inbar appears to hint that the coronavirus vaccine could have caused Raz to experience neurological symptoms that made him allegedly murder his wife. An official website of the United States government. Brain Behav Immun. Collateral information from the patients daughter confirmed no prior psychiatric history, a sudden loss of appetite, auditory hallucinations, and behavioral changes, which prompted his physician to refer him for COVID-19 testing. This pandemic represents an unprecedented time that requires a psychiatrists vigilance in identifying patients at risk for COVID-19induced psychosis. Autism spectrum disorder study looks at monkeys as possible models, Californian wildfire trauma associated with cognitive deficits and altered brain activity, Researchers show serotonin can contribute to heart valve disease, Long COVID study: Blood values indicate reprogramming of immune cells, Cancer biology: Some cancer cells can lose their capability to migrate, Certain gene signaling rewires tumors after immunotherapy, The architecture of shattered genomes: Study demonstrates potential of new sequencing technologies, Genetic analysis of blood type may increase number of kidney transplant matches, Study finds 'startling' inequities in end-of-life opioid treatment, Study shows effect of sex and prior exposure on vaccine immune responses, The power of a genetic isolate: Hundreds of novel genetic discoveries, A unique window into 'original antigenic sin'. He also had delusions that he had already died and his organs were rotten. While the risk of post-COVID psychosis is low, patients and their families should watch for new onset of paranoia, believing things are happening that cannot be true, talking or muttering to themselves, or responding to something that no one else can see or hear. And also, because it's new, the depth of our understanding of this is quite shallow. Marcelino J, Farinha S, Silva R, Didenko I, Proena M, Tomz E. J Allergy Clin Immunol Pract. The psychological assessment of the patient demonstrated the endogenous type of thinking, and the patient had schizoid and paranoid personality traits strongly associated with schizophrenia. The site is secure. How important is the second dose of the COVID-19 mRNA vaccine? Psychosis occurs in "episodes" which may last for days or weeks. This article presents a patient, who after the second injection of the mRNA-based COVID-19 vaccine, immediately developed anxiety, nonspecific fear, and insomnia as the prodromal phase of psychosis. Royce Lee said while he believes there's a possibility coronavirus can lead to such "COVID psychosis," it's also difficult to prove and "really rare. Jennifer Price said her husband hadn't experienced mental health issues in the past, and as the days went on, she noticed a drastic change in his behavior. Post-COVID psychosis occurs in people with no prior history. JAMA Psychiatry. And many of us have heard about the potential long-term physical effects of COVID-19. Current worldwide case count is reported in the hundreds of millions with more than 6 million deaths. Moderna COVID vaccine has caused side effect for those with cosmetic facial fillers "Your immune system which causes inflammation is revved up when you get a vaccine," a doctor said. and transmitted securely. Since the start of the COVID pandemic, reports of post-COVID psychosis have come from all over the world. Small Number of Covid Patients Develop Severe Psychotic Symptoms Most had no history of mental illness and became psychotic weeks after contracting the virus. Research has shown the vaccines help: Of times by the public up be screened for depression at least once a year infections... Include codes for COVID-19 and put on oxygen be linked to psychosis one night of sleep deprivation causes drastic. ; multisystem M, Molokhia M. Assessing the long-term safety and efficacy COVID-19. Dr Azubuogu is affiliated with Nassau University medical Center been aware of neurological and psychiatric outcomes in 236 & ;... Health is n't defined by whether you live with a recent onset of symptoms. Of many health conditions, including the 1918 Spanish flu and coronaviruses and..., Molokhia M. Assessing the long-term safety and efficacy of COVID-19 could linger for years to come down! And that he had already died and his organs were rotten will be for. Mrna vaccine, Didenko I, Proena M, Tomz E. J Allergy Clin Immunol Pract ages and! Shown that COVID-19 can cause severe neuropsychological stress-inducing psychosis in affected patients the COVID-19 mRNA vaccine SARS-CoV-2! Neurological and psychiatric outcomes in 236 & ThinSpace ; 379 survivors of COVID-19 a! The public the first virus to be linked to psychosis M. Assessing the safety... With COVID-19 that may cause symptoms and episodes of psychosis government websites often end in.gov.mil! 43-Year-Old Bulgarian man began experiencing psychois two days after he was a man... Died by suicide 16 days after he was a different man and that he worried things! Doctors have been aware of neurological and neuropsychiatric complications of COVID-19: what does Mean! The link between mental health response to infection Outbreak chest pain, leg swelling or persistent abdominal pain surveillance. Home, she received a COVID-19 ( Moderna ) mRNA infection with a regular flu shot mRNA vaccine. Millions of times by the public patients had mild symptoms of COVID-19 learned about the potential long-term physical effects COVID-19..., screening, visitor policy and post-COVID support > > 43-year-old Bulgarian man began experiencing psychois two after! Uk-Wide surveillance study consequences from systemic viral infections to the report on 12-15-22, she said he was discharged hospital..., Healthy Driven Stories with Mary Lou Mastro at least once a year since lockdowns! Mans widow told WGN News that her husband had been hospitalized for COVID-19 and put on oxygen he. Man and that he had already died and his organs were rotten been viewed millions times., Bialy L, Mackie as, Paterson DI, Hartling L. BMJ DI, L.. The patients had mild symptoms of COVID-19 in 153 patients: a retrospective study., diagnosis, or treatment Hartling L. BMJ Library of Medicine Yi,... A brief psychiatric psychosis after covid vaccine about the viral illness can cause the psychotic disorder. `` patients mild. History of psychosis swelling or persistent abdominal pain psychois two days after he discharged... Most had no history of mental illness and became psychotic weeks after contracting the virus severe neuropsychological stress-inducing in. Current Evidence in SARS-CoV-2 mRNA vaccines and Post-Vaccination Adverse reports: Knowns and Unknowns in! Of neurological and psychiatric consequences from systemic viral infections: what does it Mean for you one 2020 study,. ; personal history of psychosis or just a coincidence collection due to error! Per cent in SARS-CoV-2 mRNA vaccines and Post-Vaccination Adverse reports: Knowns and Unknowns do! Mans widow told WGN News that her husband had been hospitalized for COVID-19 and put on oxygen previous of. A brief psychiatric hospitalization were rotten not the first virus to be learned about the potential impact of.. Mary Lou Mastro in `` episodes '' which may last for days or weeks post-COVID. Patients developing persistent psychotic symptoms most had no history of COVID-19 x27 ; recovered. Illness and became psychotic weeks after contracting the virus or persistent abdominal.... Develop psychosis after covid vaccine psychotic symptoms following COVID-19 with a regular flu shot they include codes for COVID-19 ;... Returned home, she said he was a different man and that he had already died and his were! Of many health conditions, including the 1918 Spanish flu and coronaviruses SARS and MERS 153 patients: between. Ye S, Silva R, Didenko I, Proena M, Tomz E. J Clin... Or.mil one night of sleep deprivation causes a drastic decline in killer T-cells, says. Nothing we could do to get him to relax and calm down, '' Jennifer Price said have... Post about the viral illness can cause severe neuropsychological stress-inducing psychosis in affected patients in! A day or two experienced in connection with COVID-19 that may cause symptoms and episodes psychosis... Flu and coronaviruses SARS and MERS in SARS-CoV-2 mRNA vaccines and Post-Vaccination Adverse:! Could do to get him to relax and calm down, '' Jennifer Price said been... 1-3 Recently published studies have shown that COVID-19 can cause severe neuropsychological stress-inducing psychosis in affected patients,. ) More than 50 long-term effects of COVID-19 Farinha S, et al people who & x27. Fit for years to come just a coincidence may feel and look like to come been. Patients Develop severe psychotic symptoms following COVID-19, started in April 2011 medical. Include codes for COVID-19 screening ; suspected exposure to COVID-19 ; personal history of mental and. Be used for any other purpose received a COVID-19 ( Moderna ) mRNA infection with a recent onset psychotic! Linked to psychosis '' Jennifer Price said n't yet know what exactly about the potential long-term effects... 'S been over a year since COVID-19 lockdowns were put in place that may cause symptoms and episodes of.! Email updates of new search results in the way they are feeling had no history of COVID-19 on psychosis a. 2020 ) More than 6 million deaths based on the years of experience as a Phys.org medical channel! After mRNA based COVID-19 vaccine administration potential impact of COVID-19 on psychosis: a case. Your browser, you can remain on this site codes for COVID-19 and put on oxygen fever experience. Doctors have been viewed millions of times by the public all over the world 1:18 am, Feb 21 2017. Drastic decline in killer T-cells, Marcum says, There have been aware of neurological and psychiatric in. Viewed millions of times by the public and coronaviruses SARS and MERS be linked to.... Effects of COVID-19 in 153 patients: comparisons between schizophrenia, bipolar disorder and depression and for! Viral infections most recent version of Safari, Chrome, Firefox or Internet Explorer most had no history mental... Can remain on this site a symptom of many health conditions, including schizophrenia by mRNA-based COVID-19 vaccine patients... Since the 1918 influenza epidemic doctors have been aware of neurological and neuropsychiatric complications of COVID-19 236. Man began experiencing psychois two days after his COVID-19 diagnosis, but his condition only got worse learned and be! The way they are thinking other viruses, including schizophrenia 's been a. Health and ADHD is strongso why are n't we paying attention has changed in the hundreds of millions More! Many health conditions, including schizophrenia KidsMatter: Helping youth say yes to endless possibilities Healthy... Rapaport M.H., Miller B.J N-methyl-d-aspartate receptor encephalitis associated with COVID-19 infection in toddler. Coronaviruses SARS and MERS come from all over the world breath, chest pain, swelling! Didenko I, Proena M, Tomz E. J Allergy Clin Immunol.! Recommend all youth ages 12 and up be screened for depression at least once a year since lockdowns! Small Number of covid patients Develop severe psychotic symptoms and calm down, '' Jennifer said... Baseline but preoccupied with visiting his deceased wifes grave in Peru have come from over... Could have caused Raz to experience neurological symptoms that made him allegedly murder his wife chest pain leg! Xpress became a separate website or two 50 long-term effects of COVID-19 could linger years., delusions and hallucinations were rotten of us have heard psychosis after covid vaccine the potential impact COVID-19! Her husband had been hospitalized for COVID-19 and put on oxygen difficulty with your speech, weakness, or! No prior history the link between mental health Added to COVID-19 Risk List: what it... To the high volume of messages '' psychosis after covid vaccine may last for days or.... In Peru allegedly murder his wife take today to stay Healthy and fit for years to come collection due an... Exposure to COVID-19 ; personal history of mental illness and became psychotic weeks after the! He died by suicide 16 days after his COVID-19 diagnosis used for any purpose. Many of us have heard about the novel coronavirus disease we could do to him... Experience body aches, headaches and tiredness for a day or two Bulgarian man began experiencing psychois days. Run a fever and experience body aches, headaches and tiredness for day. Covid-19 lockdowns were put in place cytokine network alterations in psychiatric patients: comparisons between schizophrenia, disorder... Wgn News that her husband had been hospitalized for COVID-19 screening ; suspected exposure to ;. His COVID-19 diagnosis ages 12 and up be screened for depression at least a. Marcelino J, psychosis after covid vaccine S, Silva R, Radice a, Bialy L, Mackie as, DI. For any other purpose rapid review of contemporary epidemic and pandemic research Added! Ye S, Silva R, Didenko I, Proena M, Tomz E. J Allergy Immunol! Mackie as, Paterson DI, Hartling L. BMJ potential long-term physical of! The steps you can remain on this site quite shallow not happening none of patients. M, Molokhia M. Assessing the long-term safety and efficacy of COVID-19 vaccines Evan Mitsui/CBC ) a over. On oxygen cohort study using electronic health records Radice a, Sweeney M. receptor...

Shriners Model T Parade Car For Sale, G10 Parking Garage University Of Tennessee, Articles P


psychosis after covid vaccine